Genetic mechanisms for adapting to a changing environment.

INTRODUCTION ..................................................................................... 630 ANALYSIS OF GENETIC VARIATION IN FUNDULUS HETEROCLITUS: A MULTIDISCIPLINARY EXAMPLE OF CLARKE’S SUGGESTED STRATEGY ............................................................ 632 Genetic Variability in Relation to Latitude .................................................. 632 Biochemical Analysis of Allelic lsozymes .................................................... 636 A BRIEF REVIEW OF STEADY-STATE KINETIC ......................................... 637 LACTATE DEHYDROGENASE: A MODEL FOR ALLELIC ISOZYME ............... 638 Functional Differences at the Cellular Level ................................................ 646 Physiological Basis for Swimming Endurance Differences ............................... 648 Differential Hatching Times .................................................................... 650 Differential Developmental Rates .............................................................. 651 Selection Experiments ............................................................................ 652 CONCLUSION A D PROSPECTS FOR THE FUTURE .................................... 655